Endocrine Abstracts

Synthetic glucocorticoids (Gc) are the most potent anti-inflammatory agents known and are widely used to treat a range of chronic inflammatory diseases including rheumatoid arthritis and asthma. However their therapeutic utility is limited by the development of Gc resistance over time – particularly at sites of inflammation. Understanding the underlying mechanisms that control Gc sensitivity is essential to overcome this. Previous studies have measured the average transcr...